HCID 22277120, compound → HCID 22277167, compound

HRID 1063896Notes

Reaction equation

HRID 1063896 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:17][CH2:16][C:15]([CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])([C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:20][CH:19]=2)[S:14](=[O:40])(=[O:39])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[CH2:1]([O:8][C:9]([N:11]1[CH2:17][CH2:16][C:15]([CH2:31][C:32]([OH:34])=[O:33])([C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)=[CH:20][CH:19]=2)[S:14](=[O:39])(=[O:40])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 22277120HCID 22277120, compound

Product 1

HCID 22277167HCID 22277167, compoundYield 91.2%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

tert-Butyl 2-[4-benzyloxycarbonyl-7-(4-phenoxyphenyl)perhydro-1,1-dioxo-1,4-thiazepin-7-yl]acetate (56 mg) was dissolved in trifluoroacetic acid (6 ml) at room temperature. After being stirred at the same temperature for 2 hours, the reaction mixture was concentrated in vacuo to give 2-[4-benzyloxycarbonyl-7-(4-phenoxyphenyl)perhydro-1,1-dioxo-1,4-thiazepin-7-yl]acetic acid (46 mg) as a powder.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-5fd3b8425d99409b9058a94e174b9b48
Source dataset
uspto-grants-2005_11
Patent number
US06967197B2

Reaction notes

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