Hydrogen chloride-ethyl acetate → 4-Methoxypiperidine hydrochloride

HRID 1063903Notes

Reaction equation

HRID 1063903 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][CH3:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:16].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:16].[CH3:15][O:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 21955381Tert-butyl 4-methoxypiperidine-1-carboxylate

Product 1

HCID 115428134-Methoxypiperidine hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 1-t-butoxycarbonyl-4-methoxypiperidine (2.84 g) in ethyl acetate (20 ml) was added 4N hydrochloric-acid-ethyl acetate solution (20 ml) and the mixture was stirred at ambient temperature for 1 hour. The solution was evaporated in vacuo to give 4-methoxypiperidine hydrochloride as a colorless amorphous powder (2.03 g).

Workup

  1. customThe solution was evaporated in vacuo

Sources & evidence

ORD record
ord-2d6136925d4b44468b2c7502ff564973
Source dataset
uspto-grants-2005_11
Patent number
US06967197B2

Reaction notes

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