Hydrochloride methanol → HCID 22276861, compound

HRID 1063922Notes

Reaction equation

HRID 1063922 reaction equation
[OH:1][NH:2][C:3](=[O:38])[CH2:4][C@@:5]1([C:22]2[S:23][C:24]([C:27]3[CH:32]=[CH:31][C:30]([C:33]4[O:37][CH:36]=[N:35][CH:34]=4)=[CH:29][CH:28]=3)=[CH:25][CH:26]=2)[S:11](=[O:13])(=[O:12])[CH2:10][CH2:9][N:8]([C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)=[O:15])[CH2:7][CH2:6]1.[ClH:39].CO>CO>[ClH:39].[OH:1][NH:2][C:3](=[O:38])[CH2:4][C:5]1([C:22]2[S:23][C:24]([C:27]3[CH:32]=[CH:31][C:30]([C:33]4[O:37][CH:36]=[N:35][CH:34]=4)=[CH:29][CH:28]=3)=[CH:25][CH:26]=2)[S:11](=[O:13])(=[O:12])[CH2:10][CH2:9][N:8]([C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)=[O:15])[CH2:7][CH2:6]1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 86588738HCID 86588738, compound

Product 1

HCID 22276861HCID 22276861, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of N-hydroxy-2-[(S)-7-(5-(4-(5-oxazolyl)phenyl)-2-thienyl)-4-(2-pyridinecarbonyl)-1,1-dioxoperhydro-1,4-thiazepin-7-yl]acetamide (118 mg) in methanol (3 ml) was added 10% hydrochloric acid-methanol solution (5 ml) and the mixture was stirred at ambient temperature for 0.5 hour. After evaporation of solvent, the residue was triturated with isopropyl ether to give N-hydroxy-2-[7-(5-(4-(5-oxazolyl)phenyl)-2-thienyl)-4-(2-pyridinecarbonyl)-1,1-dioxoperhydro-1,4-thiazepin-7-yl]acetamide hydrochloride as a pale yellow amorphous powder (119 mg).

Workup

  1. customAfter evaporation of solvent
  2. customthe residue was triturated with isopropyl ether

Sources & evidence

ORD record
ord-a3b56ff62e36481aad857c5a00e036dc
Source dataset
uspto-grants-2005_11
Patent number
US06967197B2

Reaction notes

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