Hydrochloride methanol → HCID 22276861, compound

Participants

Reaction Steps

To a solution of N-hydroxy-2-[(S)-7-(5-(4-(5-oxazolyl)phenyl)-2-thienyl)-4-(2-pyridinecarbonyl)-1,1-dioxoperhydro-1,4-thiazepin-7-yl]acetamide (118 mg) in methanol (3 ml) was added 10% hydrochloric acid-methanol solution (5 ml) and the mixture was stirred at ambient temperature for 0.5 hour. After evaporation of solvent, the residue was triturated with isopropyl ether to give N-hydroxy-2-[7-(5-(4-(5-oxazolyl)phenyl)-2-thienyl)-4-(2-pyridinecarbonyl)-1,1-dioxoperhydro-1,4-thiazepin-7-yl]acetamide hydrochloride as a pale yellow amorphous powder (119 mg).

Provenance & Evidence