2-[(Methylsulfonyl)methyl]piperidine → HCID 86759906, compound

HRID 1063961Notes

Reaction equation

HRID 1063961 reaction equation
ClC1C=CC(S(N(C2C=C(Cl)C=CC=2Cl)[C@H:12]([CH3:26])[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH:16]2[CH2:21][S:22]([CH3:25])(=[O:24])=[O:23])(=O)=O)=CC=1.Cl[C:36]1[CH:41]=[CH:40][C:39]([S:42]([N:45](C2C=C(Cl)C=CC=2Cl)[C@H](C)CCCBr)(=[O:44])=[O:43])=[CH:38][CH:37]=1.[CH3:60]S(CC1CCCCN1)(=O)=O>C(Cl)Cl>[CH3:25][S:22]([CH2:21][CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][N:15]1[C@:14]([C:36]1[CH:37]=[CH:38][C:39]([S:42]([NH2:45])(=[O:43])=[O:44])=[CH:40][CH:41]=1)([CH3:60])[CH2:13][CH2:12][CH3:26])(=[O:23])=[O:24]

Participants

5

Reactant 3

HCID 222752132-[(Methylsulfonyl)methyl]piperidineHCID 23401651HCID 23401651, compoundHCID 23401686HCID 23401686, compound

Product 1

HCID 86759906HCID 86759906, compoundYield 28%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-chloro-N-(2,5-dichlorophenyl)-N-[4-[[2-(methylsulfonyl)methyl-1-piperidinyl]-1(R)-methylbutyl]benzenesulfonamide was prepared analogous to 4-chloro-N-(2,5-dichlorophenyl)-N-(3-(2-((methylsulfonyl)methyl)-1-piperidinyl)-1(R)-methylpropyl)benzenesulfonamide by reacting 4-chloro-N-[2,5-dichlorophenyl]-N-[(R)-1-methyl-4-bromobutyl]benzenesulfonamide with 2-(methylsulfonylmethyl)piperidine. Yield=28%; yellow foam: IR (neat, CH2Cl2) 1467, 1296, 1166, 1138, 1095, 622, cm−1; MS (ESI+), 581 (M+H)+.

Sources & evidence

ORD record
ord-a50740ec1fe04d5aa239188009591bc1
Source dataset
uspto-grants-2005_11
Patent number
US06967196B1

Reaction notes

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