Potassium Hydroxide → HCID 23401698, compound

HRID 1063964Notes

Reaction equation

HRID 1063964 reaction equation
ClC1C=CC(S(N(C2C=C(Cl)C=CC=2Cl)[C@H](C)CCN2CCSC2[C:20]([OH:22])=[O:21])(=O)=O)=CC=1.[Cl:32][C:33]1[CH:38]=[CH:37][C:36]([S:39]([N:42]([C:58]2[CH:63]=[C:62]([Cl:64])[CH:61]=[CH:60][C:59]=2[Cl:65])[C@H:43]([CH3:57])[CH2:44][CH2:45][CH2:46][CH2:47][N:48]2[CH2:52][CH2:51][S:50][CH:49]2CC(O)=O)(=[O:41])=O)=[CH:35][CH:34]=1.[OH-:66].[K+]>C(Cl)Cl>[Cl:32][C:33]1[CH:34]=[CH:35][C:36]([S:39]([N:42]([C:58]2[CH:63]=[C:62]([Cl:64])[CH:61]=[CH:60][C:59]=2[Cl:65])[C@H:43]([CH3:57])[CH2:44][CH2:45][CH2:46][CH2:47][N:48]2[CH2:52][CH2:51][S:50][CH:49]2[C:20]([OH:22])=[O:21])(=[O:41])=[O:66])=[CH:37][CH:38]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 23401648HCID 23401648, compoundHCID 23401699HCID 23401699, compound

Product 1

HCID 23401698HCID 23401698, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-chloro-N-(2,5-dichlorophenyl)-N-(5-(2-carboxy-3-thiazolidinyl)-1(R)-methylpentyl)benzenesulfonamide was prepared analogous to 4-chloro-N-(2,5-dichlorophenyl)-N-(3-(2-carboxy-3-thiazolidinyl)-1(R)-methylpropyl)benzenesulfonamide by reacting 4-chloro-N-(2,5-dichlorophenyl)-N-(5-(2-carboxymethyl-3-thiazolidinyl)-1(R)-methylpentyl)benzenesulfonamide with 50% aqueous KOH. Yield=67%; White foam: IR (neat, CH2Cl2) 1467, 1350, 1167, 1093, 753, 622 cm−1; MS (ESI+), 553 (M+H)+.

Sources & evidence

ORD record
ord-e1b9a1ada35c402b9d96e0ae472f7818
Source dataset
uspto-grants-2005_11
Patent number
US06967196B1

Reaction notes

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