Benzenesulfonamide → HCID 86759908, compound

HRID 1063971Notes

Reaction equation

HRID 1063971 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11](C2C=C(Cl)C=CC=2Cl)[C@H:12]([CH3:20])[CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:19])[CH3:18])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:29]1(S(N)(=O)=O)[CH:34]=[CH:33]C=[CH:31][CH:30]=1.C(Cl)(=O)C1C=CC=CC=1>>[C:18]1([C:17]([NH:16][CH2:15][CH2:14][CH2:13][C@H:12]([NH:11][S:8]([C:5]2[CH:4]=[CH:3][CH:2]=[CH:7][CH:6]=2)(=[O:9])=[O:10])[CH3:20])=[O:19])[CH:33]=[CH:34][CH:29]=[CH:30][CH:31]=1

Participants

4

Reactant 3

HCID 7370BenzenesulfonamideHCID 7412Benzoyl chlorideHCID 23401683HCID 23401683, compound

Product 1

HCID 86759908HCID 86759908, compoundYield 84%

Procedure

4-chloro-N-2,5-dichlorophenyl)-N-(4-[[(phenyl)carbonyl]amino]-1(R)-methylbutyl]benzenesulfonamide was prepared analogous to 4-chloro-N-[2,5-dichlorophenyl]-N-[(R)-1-methyl-4-(acetylamino)butyl]benzenesulfonamide by reacting 4-chloro-N-[2,5-dichlorophenyl]-N-[R]-1-methyl-4-aminobutyl]benzenesulfonamide with benzoyl chloride. Yield=84%; MS (ESI+), 525 (M+H)+.

Sources & evidence

ORD record
ord-6274eecdefeb44a8af8e62fb4d3ac8fa
Source dataset
uspto-grants-2005_11
Patent number
US06967196B1

Reaction notes

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