Methyl chloroformate → HCID 86759909, compound

HRID 1063972Notes

Reaction equation

HRID 1063972 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11](C2C=C(Cl)C=CC=2Cl)[C@H:12]([CH3:20])[CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:19])C)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C1(S(N)(=O)=O)C=CC=CC=1.Cl[C:40](OC)=[O:41]>>[CH3:40][O:41][C:17]([NH:16][CH2:15][CH2:14][CH2:13][C@H:12]([NH:11][S:8]([C:5]1[CH:4]=[CH:3][CH:2]=[CH:7][CH:6]=1)(=[O:9])=[O:10])[CH3:20])=[O:19]

Participants

4

Reactant 3

HCID 6586Methyl chloroformateHCID 7370BenzenesulfonamideHCID 23401683HCID 23401683, compound

Product 1

HCID 86759909HCID 86759909, compoundYield 96%

Procedure

4-chloro-N-2,5-dichlorophenyl)-N-[4-[[(methoxy)carbonyl]amino]-1(R)-methylbutyl]benzenesulfonamide was prepared analogous to 4-chloro-N-[2,5-dichlorophenyl]-N-[(R)-1-methyl-4-(acetylamino)butyl]benzenesulfonamide by reacting 4-chloro-N-[2,5-dichlorophenyl]-N-[R]-1-methyl-4-aminobutyl]benzenesulfonamide with methyl chloroformate. Yield=96%; MS (ESI+), 479 (M+H)+.

Sources & evidence

ORD record
ord-365fda323d7f4b9e9ae0f2a8df9c328e
Source dataset
uspto-grants-2005_11
Patent number
US06967196B1

Reaction notes

Loading…