Dimethylamine → HCID 23401747, compound

HRID 1063979Notes

Reaction equation

HRID 1063979 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([C:22]2[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:23]=2[CH2:29][OH:30])[C@H:12]([CH3:21])[CH2:13][CH2:14][CH2:15][S:16]([NH:19]C)(=[O:18])=[O:17])(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(S(Cl)(=O)=O)CCCC.[CH3:40][NH:41][CH3:42]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([C:22]2[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:23]=2[CH2:29][OH:30])[C@H:12]([CH3:21])[CH2:13][CH2:14][CH2:15][S:16]([NH:19][N:41]([CH3:42])[CH3:40])(=[O:17])=[O:18])(=[O:9])=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 674DimethylamineHCID 2375551-Pentanesulfonyl chlorideHCID 23401749HCID 23401749, compound

Product 1

HCID 23401747HCID 23401747, compoundYield 73%

Procedure

4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]-N-[4-(dimethylaminoaminosulfonyl)-1(R)-methylbutyl]-benzenesulfonamide was prepared analogous to 4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]-N-[4-[(methylamino)sulfonyl]-1(R)-methylbutyl]benzenesulfonamide by reacting (4R)-4-[5-chloro-2-(acetoxymethyl)phenyl][4-chlorophenyl)sulfonyl]-amino]pentylsulfonyl chloride with dimethylamine. Yield=73%; MS (ESI+), 509 (M+H)+.

Sources & evidence

ORD record
ord-190edd642c2e48d381519e7d5bc0b149
Source dataset
uspto-grants-2005_11
Patent number
US06967196B1

Reaction notes

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