Hydrochloric Acid → HCID 22277805, compound

HRID 1064027Notes

Reaction equation

HRID 1064027 reaction equation
Cl.[CH3:2][N:3]([CH2:14][CH2:15][CH2:16][S:17]([CH3:20])(=[O:19])=[O:18])C(OCC1C=CC=CC=1)=O>CO.[Pd]>[CH3:2][NH:3][CH2:14][CH2:15][CH2:16][S:17]([CH3:20])(=[O:19])=[O:18]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22277829HCID 22277829, compound

Product 1

HCID 22277805HCID 22277805, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Ethereal HCl (22.5 ml, 1 M solution) was added to a stirred solution of N-methyl-N-(3-mesylpropyl)-N-(benzyloxycarbonyl)amine (Method 14; 5 g) in methanol (100 ml). 10% Pd/C (1.25 g) was added and the mixture was stirred under an atmosphere of hydrogen for 2 hrs. The catalyst was removed by filtration and the filtrate evaporated to dryness. Trituration with ether gave the product as a white solid. NMR (DMSO-d6+d4-acetic acid) 2.11 (m, 2H), 2.59 (s, 3H), 3.0 (s, 3H), 3.05 (t, 2H); m/z 152.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated to dryness

Sources & evidence

ORD record
ord-d91306f51dc94f6c80e96caeac2af339
Source dataset
uspto-grants-2005_11
Patent number
US06967216B2

Reaction notes

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