Hydrazine → 4-(4-Chloro-phenyl)-5-pyridin-4-yl-pyrazolidin-3-one

HRID 1064072Notes

Reaction equation

HRID 1064072 reaction equation
C[O:2][C:3](=O)[C:4]([C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1)=[CH:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1.[NH2:20][NH2:21]>C(O)C>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([CH:4]2[CH:5]([C:6]3[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=3)[NH:21][NH:20][C:3]2=[O:2])=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 69356330HCID 69356330, compound

Product 1

HCID 222779894-(4-Chloro-phenyl)-5-pyridin-4-yl-pyrazolidin-3-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of 2-(4-Chloro-phenyl)-3-pyridin-4-yl-acrylic acid methyl ester 2.02 g in ethyl alcohol 25 mL was added hydrazine 2.37 g. The reaction was heated to 50° C. for 135 minutes. All solvent was removed after under reduced pressure to afford the title compound as light yellow solid. MS (ES+): 274 (M+H)+.

Workup

  1. customAll solvent was removed after under reduced pressure

Sources & evidence

ORD record
ord-d7fe7a69bcd14183b4ac978d02affae1
Source dataset
uspto-grants-2005_11
Patent number
US06967254B2

Reaction notes

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