Trifluoroacetic acid → HCID 137241992, compound

HRID 1064139Notes

Reaction equation

HRID 1064139 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:17](=[O:39])[NH:18][C:19]1[CH:20]=[C:21]2[C:37](=[O:38])[NH:36][N:35]=[CH:34][C:23]3=[C:24]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[NH:25][C:26]([CH:27]=1)=[C:22]23)[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(C)(C)C.[C:41]([OH:47])([C:43]([F:46])([F:45])[F:44])=[O:42]>C(Cl)Cl>[F:44][C:43]([F:46])([F:45])[C:41]([OH:47])=[O:42].[NH2:7][C@@H:8]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:17]([NH:18][C:19]1[CH:20]=[C:21]2[C:37](=[O:38])[NH:36][N:35]=[CH:34][C:23]3=[C:24]([C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)[NH:25][C:26]([CH:27]=1)=[C:22]23)=[O:39]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 136181666HCID 136181666, compound

Product 1

HCID 137241992HCID 137241992, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Preparation of example 54 from the title compound of Example 53 (30 mg, 0.056 mmol) and 45% TFA in CH2Cl2 (1 mL) was carried out analogously to Example 20. Isolation, also in an analogous manner, afforded the title compound (26 mg, 0.047 mmol) as a yellow powder in 84% yield.

Sources & evidence

ORD record
ord-b80328e7b34c480ab2b71a596b7c2b35
Source dataset
uspto-grants-2005_11
Patent number
US06967198B2

Reaction notes

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