Hydrochloric Acid → (1R,2R)-2-Phenyl-cyclopropanecarboxylic Acid [2-(3-dimethylaminomethyl-phenyl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-amide HCl Salt

HRID 1064149Notes

Reaction equation

HRID 1064149 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([C:11]2[NH:12][C:13]3[CH:14]=[C:15]([NH:25][C:26]([C@@H:28]4[CH2:30][C@H:29]4[C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[O:27])[CH:16]=[C:17]4[C:23](=[O:24])[NH:22][N:21]=[CH:20][C:19]=2[C:18]=34)[CH:8]=[CH:9][CH:10]=1)[CH3:3].[ClH:37].O1CCOCC1>ClCCl>[ClH:37].[CH3:3][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([C:11]2[NH:12][C:13]3[CH:14]=[C:15]([NH:25][C:26]([C@@H:28]4[CH2:30][C@H:29]4[C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[O:27])[CH:16]=[C:17]4[C:23](=[O:24])[NH:22][N:21]=[CH:20][C:19]=2[C:18]=34)[CH:8]=[CH:9][CH:10]=1)[CH3:1]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 136141630(1r,2r)-2-Phenyl-cyclopropanecarboxylic acid [2-(3-dimethylaminomethyl-phenyl)-6-oxo-5,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl]-amide

Product 1

HCID 137241993(1R,2R)-2-Phenyl-cyclopropanecarboxylic Acid [2-(3-dimethylaminomethyl-phenyl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-amide HCl Salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound of Example 83a (0.075 g, 0.16 mmol) in dichloromethane (1.0 mL) was treated with 4M HCl in dioxane (0.043 mL, 0.17 mmol). After concentrating to dryness, the title compound (0.08 g) was obtained in quantitative yield.

Workup

  1. concentrationAfter concentrating to dryness

Sources & evidence

ORD record
ord-41d4e43723dc4c1e96cc63174453358c
Source dataset
uspto-grants-2005_11
Patent number
US06967198B2

Reaction notes

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