Hydrochloric Acid → HCID 136411686, compound

HRID 1064164Notes

Reaction equation

HRID 1064164 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[C:14](=[O:36])[NH:15][C:16]1[CH:17]=[C:18]2[C:34](=[O:35])[NH:33][N:32]=[CH:31][C:20]3=[C:21]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[NH:22][C:23]([CH:24]=1)=[C:19]23)=O)(C)(C)C.Cl.O1CCOCC1>>[O:35]=[C:34]1[C:18]2[C:19]3[C:20](=[C:21]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[NH:22][C:23]=3[CH:24]=[C:16]([NH:15][C:14]([C@@H:9]3[CH2:10][CH2:11][CH2:12][CH2:13][NH:8]3)=[O:36])[CH:17]=2)[CH:31]=[N:32][NH:33]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 136401903HCID 136401903, compound

Product 1

HCID 136411686HCID 136411686, compound

Procedure

Preparation of the title compound from Intermediate 137(a) (0.16 g, 0.33 mmol) and 4M HCl in dioxane (1.6 mL, 6.6 mmol) was carried out analogously to Example 91. Isolation, also in an analogous manner, included a further trituration with CH2Cl2/diethyl ether and afforded the title compound (0.132 g) as an orange/yellow powder in 95% yield.

Sources & evidence

ORD record
ord-34ed727844164d91b23171a1aee9dc81
Source dataset
uspto-grants-2005_11
Patent number
US06967198B2

Reaction notes

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