Hydrochloric Acid → HCID 136141793, compound

HRID 1064165Notes

Reaction equation

HRID 1064165 reaction equation
C(OC([N:8]1[CH2:12][C@H:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][C@H:9]1[C:21](=[O:37])[NH:22][C:23]1[CH:24]=[C:25]2[C:35](=[O:36])[NH:34][N:33]=[CH:32][C:27]3=[CH:28][NH:29][C:30]([CH:31]=1)=[C:26]23)=O)(C)(C)C.Cl.O1CCOCC1>>[O:36]=[C:35]1[C:25]2[C:26]3[C:27](=[CH:28][NH:29][C:30]=3[CH:31]=[C:23]([NH:22][C:21]([C@@H:9]3[CH2:10][C@@H:11]([O:13][CH2:14][C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH2:12][NH:8]3)=[O:37])[CH:24]=2)[CH:32]=[N:33][NH:34]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 136181611HCID 136181611, compound

Product 1

HCID 136141793HCID 136141793, compound

Procedure

Preparation of the title compound from Intermediate 142(a) (0.106 g, 0.21 mmol) and 4M HCl in dioxane (1 mL, 4.2 mmol) was carried out analogously to Example 91. Isolation, also in an analogous manner, included a further trituration with CH2Cl2/diethyl ether and afforded the title compound (0.085 g) as an orange/yellow powder in 92% yield.

Sources & evidence

ORD record
ord-7185fef56d514aac9ee90682f275e079
Source dataset
uspto-grants-2005_11
Patent number
US06967198B2

Reaction notes

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