Hydrochloric Acid → HCID 136401945, compound

HRID 1064184Notes

Reaction equation

HRID 1064184 reaction equation
[O:1]=[C:2]([NH:21][C:22]1[CH:23]=[C:24]2[C:34](=[O:35])[NH:33][N:32]=[CH:31][C:26]3=[CH:27][NH:28][C:29]([CH:30]=1)=[C:25]23)[C@H:3]([NH:13]C(=O)OC(C)(C)C)[CH2:4][O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[ClH:36]>O1CCOCC1>[ClH:36].[NH2:13][C@H:3]([CH2:4][O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:2]([NH:21][C:22]1[CH:23]=[C:24]2[C:34](=[O:35])[NH:33][N:32]=[CH:31][C:26]3=[CH:27][NH:28][C:29]([CH:30]=1)=[C:25]23)=[O:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136181609HCID 136181609, compound

Product 1

HCID 136401945HCID 136401945, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Preparation of example 177 from the title compound of Example 159 (35 mg, 0.072 mmol) and 4M HCl in dioxane (10 mL) was carried out analogously to Example 91. Isolation, also in an analogous manner afforded the title compound (30 mg, 0.072 mmol) as an orange/yellow powder in 100% yield.

Sources & evidence

ORD record
ord-9e9665cc66534453a2736c020e96d659
Source dataset
uspto-grants-2005_11
Patent number
US06967198B2

Reaction notes

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