Hydrochloric Acid → HCID 136141618, compound

HRID 1064193Notes

Reaction equation

HRID 1064193 reaction equation
C(OC(=O)[NH:7][CH:8]([C:15](=[O:32])[NH:16][C:17]1[CH:18]=[C:19]2[C:30](=[O:31])[NH:29][N:28]=[CH:27][C:21]3=[C:22]([Cl:26])[NH:23][C:24]([CH:25]=1)=[C:20]23)[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)(C)(C)C.Cl>O1CCOCC1>[NH2:7][C@H:8]([CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)[C:15]([NH:16][C:17]1[CH:18]=[C:19]2[C:30](=[O:31])[NH:29][N:28]=[CH:27][C:21]3=[C:22]([Cl:26])[NH:23][C:24]([CH:25]=1)=[C:20]23)=[O:32]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136411688HCID 136411688, compound

Product 1

HCID 136141618HCID 136141618, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Preparation of the title compound from Intermediate 198(a) (75 mg, 0.159 mmol) and 4.0 M HCl in dioxane (0.8 mL) was carried out analogously to Example 91. Isolation, also in an analogous manner, afforded the title compound (65 mg, 0.159 mmol) as a yellow powder in 99% yield.

Sources & evidence

ORD record
ord-891004c398c6434e8afa00cec73f9788
Source dataset
uspto-grants-2005_11
Patent number
US06967198B2

Reaction notes

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