Hydrochloric Acid → HCID 178424012, compound

HRID 1064208Notes

Reaction equation

HRID 1064208 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]3[CH:11]=[C:12]([NH:22]C(=O)OC(C)(C)C)[CH:13]=[C:14]4[C:20](=[O:21])[NH:19][N:18]=[CH:17][C:16]=2[C:15]=34)=[CH:4][CH:3]=1.[ClH:30]>>[Cl-:30].[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]3[CH:11]=[C:12]([NH3+:22])[CH:13]=[C:14]4[C:20](=[O:21])[NH:19][N:18]=[CH:17][C:16]=2[C:15]=34)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 136181665HCID 136181665, compound

Product 1

HCID 178424012HCID 178424012, compound

Procedure

Compound 267 (b) was obtained by reacting tert-butyl [2-(6-methylpyridin-3-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]carbamate with 4M HCl in dioxanes. Product 267(b) was isolated in quantitative yield as an orange powder after filtration and ether rinse and was carried on without further purification.

Sources & evidence

ORD record
ord-f9e5181e159a4be38aa18118877d3699
Source dataset
uspto-grants-2005_11
Patent number
US06967198B2

Reaction notes

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