HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Oxopropiononitrile → 6-Benzyloxy-5-methyl-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yloxy)-pyrrolo[2,1-f][1,2,4]triazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Oxopropiononitrile | HCID 69430 | — |
| Reactant | 6-Benzyloxy-4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine | HCID 11637630 | — |
| Reactant | 2-methyl-1H-pyrrolo[2,3-b]pyridin-5-ol | HCID 22273621 | — |
| Product | 6-Benzyloxy-5-methyl-4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yloxy)-pyrrolo[2,1-f][1,2,4]triazine | HCID 22273637 | — |
Reaction Steps
5-Hydroxy-2-methyl-7-azaindole was treated with of 6-benzyloxy-4-chloro-5-methyl-pyrrolo[2,1-f][1,2,4]triazine (see WO 0071129) by a method similar to the preparation of Example 1. 1H NMR (400 MHz, DMSO-d6) δ 8.02 (1H, br. s), 7.85 (1H, s), 7.83 (1H, s), 7.70 (1H, br. s), 7.41 (6H, m), 6.15 (1H, br. s), 5.12 (2H, s) 2.92 (3H, s), 2.42 (3H, s). m/z 386 (M+H)+, 427 (M++AcCN).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06969717B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-bebb45a7880e4264803238f616b8867f |
| Source note | uspto-grants-2005_11 |