反应详情

Selenium dioxide (0.556 g, 5.00 mmol) dissolved in 1,4dioxane:water (4:1, 5 ml) was added in one portion to 5′-acetyl-4,2′-difluorobiphenyl-2-carbonitrile (0.92 g, 3.58 mmol) in 1,4-dioxane (10 ml) and the mixture heated at reflux for 18 h. The reaction was allowed to cool to room temperature, filtered and the filtrate evaporated to give an orange-coloured glassy solid which was used without further purification (0.97 g).

1. temperaturethe mixture heated
2. temperatureat reflux for 18 h
3. filtrationfiltered
4. customthe filtrate evaporated
5. customto give an orange-coloured glassy solid which
6. customwas used without further purification (0.97 g)