2-Fluorophenylboronic acid → 5-(2,2'-Difluorobiphenyl-5-yl)-3-(2,4-difluorophenyl)-[1,2,4]triazine

Participants

Reaction Steps

5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine was coupled to 2-fluorophenylboronic acid by the method of Example 12 to give 5-(2,2′-difluorobiphenyl-5-yl)-3-(2,4-difluorophenyl)-[1,2,4]triazine as a fluffy yellow solid: δH (400 MHz, CDCl3) 6.99-7.10 (2H, m), 7.21-7.23 (1H, m), 7.27-7.31 (1H, m), 7.37-7.48 (3H, m), 8.29-8.35 (3H, m), 9.64 (1H, s); m/z (ES+) 382.

Provenance & Evidence