HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine → 3,2'-Difluoro-5'-[3-(2,4-difluorophenyl)-[1,2,4]triazin-5-yl]biphenyl-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine | HCID 10384255 | — |
| Reactant | 2-Cyano-3-fluorophenylboronic acid pinacol ester | HCID 22273603 | — |
| Product | 3,2'-Difluoro-5'-[3-(2,4-difluorophenyl)-[1,2,4]triazin-5-yl]biphenyl-2-carbonitrile | HCID 10092721 | — |
Reaction Steps
5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine was coupled to 6-fluoro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile by the method of Example 12 to give 3,2′-difluoro-5′-[3-(2,4-difluorophenyl)-[1,2,4]triazin-5-yl]biphenyl-2-carbonitrile as a yellow solid: δH (400 MHz, CDCl3) 6.99-7.11 (2H, m), 7.32-7.40 (2H, m), 7.47 (1H, t, J 9.2 Hz), 7.70-7.76 (1H, m), 8.30-8.40 (3H, m), 9.66 (1H, s); m/z(ES+) 407.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06969716B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-6b6bae67751f45b0911a416d109b5fdd |
| Source note | uspto-grants-2005_11 |