Selenium Dioxide → (4-Fluoro-3-trifluoromethylphenyl)oxoacetaldehyde

HRID 1064285Notes

Reaction equation

[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[C:6]([C:11]([F:14])([F:13])[F:12])[CH:5]=1)=[O:3].[Se](=O)=[O:16]>>[F:10][C:7]1[CH:8]=[CH:9][C:4]([C:2](=[O:3])[CH:1]=[O:16])=[CH:5][C:6]=1[C:11]([F:14])([F:12])[F:13]

Participants

Reactant 2

HCID 24007Selenium Dioxide

HCID 6056784'-Fluoro-3'-(trifluoromethyl)acetophenone

Product 1

HCID 22273600(4-Fluoro-3-trifluoromethylphenyl)oxoacetaldehyde

Procedure

4-Fluoro-3-(trifluoromethyl)acetophenone (2 g, 9.70 mmol) was reacted with selenium dioxide (1.6 g, 14.6 mmol) using the method described in Example 1 to give crude (4-fluoro-3-trifluoromethylphenyl)-oxoacetaldehyde as a yellow oil: m/z (ES+) 221.

Sources & evidence

ORD record: ord-e295bd61f523471fa13e909d7788d451
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06969716B2

Reaction notes

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