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(3-Trifluoromethylsulfanylphenyl)oxoacetaldehyde → 3-(2,4-Difluorophenyl)-5-(3-trifluoromethylsulfanylphenyl)-[1,2,4]triazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (3-Trifluoromethylsulfanylphenyl)oxoacetaldehyde | HCID 22273584 | — |
| 反応物 | HCID 178506601 | HCID 178506601 | — |
| 生成物 | 3-(2,4-Difluorophenyl)-5-(3-trifluoromethylsulfanylphenyl)-[1,2,4]triazine | HCID 11726561 | — |
反応手順
(3-Trifluoromethylsulfanylphenyl)oxoacetaldehyde was reacted with 2,4-difluorobenzenecarboximidic hydrazide hydriodide salt (1.13 g, 3.78 mmol) using the method described in Example 1 to give 3-(2,4-difluorophenyl)-5-(3-trifluoromethylsulfanylphenyl)-[1,2,4]triazine as a yellow solid (1.0 g): δH (400 MHz, CDCl3) 7.01-7.13 (2H, m), 7.68 (1H, t, J 7.8 Hz), 7.92 (1H, d, J 7.4 Hz), 8.32-8.39 (2H, m), 8.55 (1H, s), 9.67 (1H, s); m/z (ES+) 370.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06969716B2 |
| 出典データセット | uspto-grants-2005_11 |
| ORD ID | ord-d325ec458794415382dd5d0563e263c5 |
| 出典メモ | uspto-grants-2005_11 |