(3-Trifluoromethylsulfanylphenyl)oxoacetaldehyde → 3-(4-Methoxyphenyl)-5-(3-trifluoromethylsulfanylphenyl)-[1,2,4]triazine

HRID 1064292Notes

Reaction equation

HRID 1064292 reaction equation
[F:1][C:2]([S:5][C:6]1[CH:7]=[C:8]([C:12](=O)[CH:13]=O)[CH:9]=[CH:10][CH:11]=1)([F:4])[F:3].I.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]([NH:27][NH2:28])=[NH:26])=[CH:21][CH:20]=1>>[CH3:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[N:27]=[N:28][CH:13]=[C:12]([C:8]3[CH:9]=[CH:10][CH:11]=[C:6]([S:5][C:2]([F:1])([F:3])[F:4])[CH:7]=3)[N:26]=2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 22273584(3-Trifluoromethylsulfanylphenyl)oxoacetaldehydeHCID 178491255HCID 178491255, compound

Product 1

HCID 100672603-(4-Methoxyphenyl)-5-(3-trifluoromethylsulfanylphenyl)-[1,2,4]triazine

Procedure

(3-Trifluoromethylsulfanylphenyl)oxoacetaldehyde was reacted with 4-methoxybenzenecarboximidic hydrazide hydriodide salt (1.11 g, 3.78 mmol) using the method described in Example 1 to give 3-(4-methoxyphenyl)-5-(3-trifluoromethylsulfanylphenyl)-[1,2,4]triazine as a yellow solid (820 g): δH (400 MHz, CDCl3) 3.92 (3H, s), 7.06-7.10 (2H, m), 7.67 (1H, t, J 7.8 Hz), 7.90 (1H, d, J 7.8 Hz), 8.35-8.39 (1H, m), 8.56 (1H, s), 8.60-8.64 (2H, m), 9.55 (1H, s); m/z (ES+) 364.

Sources & evidence

ORD record
ord-793728741e234943bcebd17f28f86f45
Source dataset
uspto-grants-2005_11
Patent number
US06969716B2

Reaction notes

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