反应详情

温度

150 °C

Into a solution of 20.02 g of 4,5-dichloro-2-nitroaniline and 8.70 g of piperazine in 100 ml of cyclohexanol, 12.80 g of sodium carbonate was added and stirred at 150° C. for 14 hours. Cooling the reaction liquid to room temperature, water was added and the system was extracted with chloroform. The chloroform layer was dried on anhydrous magnesium sulfate and the solvent was distilled off. Thus obtained residue was washed with diisopropyl ether to provide 21.07 g of 4-chloro-2-nitro-5-(piperazin-1-yl) aniline as a yellow powder.

1. temperatureCooling
2. customthe reaction liquid to room temperature
3. extractionthe system was extracted with chloroform
4. dry with materialThe chloroform layer was dried on anhydrous magnesium sulfate
5. distillationthe solvent was distilled off
6. washThus obtained residue was washed with diisopropyl ether