反应详情

温度

30 °C

19 g (0.1 mol) of methyl 3-(4,4,4-trifluoro-3-oxo-1-butenylamino)acrylate were dissolved in 200 ml of methanol in a three-neck flask and 1 g of Li2CO3 was added. The reaction mixture was heated for 6-8 h under reflux, cooled to 30° C. and 10 ml of aqueous HCl were added. The reaction mixture was stirred for 1 h, the methanol removed under reduced pressure and the product extracted with diethyl ether. The solvent was removed and methyl 4-trifluoronicotinate purified by vacuum distillation. 14 g (81%) of the product having a boiling point of 80° C./18 mbar were obtained.

1. temperatureThe reaction mixture was heated for 6-8 h
2. temperatureunder reflux
3. customthe methanol removed under reduced pressure
4. extractionthe product extracted with diethyl ether
5. customThe solvent was removed
6. distillationmethyl 4-trifluoronicotinate purified by vacuum distillation
7. customwere obtained