HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-N-(2-oxo-2,3-dihydro-1H-indol-4-yl)acetamide Hydrochloride Salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 3-[(2-Oxo-2,3-dihydro-1H-indol-4ylcarbamoyl)-methyl]-3,8-diazabicyclo[3.2.1]octan-8-carboxylic acid, 1,1-dimethylethyl Ester | HCID 86602000 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-N-(2-oxo-2,3-dihydro-1H-indol-4-yl)acetamide Hydrochloride Salt | HCID 69797777 | — |
Reaction Steps
The product of step (ii) (0.8 g) was dissolved in 2M hydrogen chloride in 1,4-dioxane (10 ml), 1,4-dioxane (10 ml), methanol (10 ml) and the reaction mixture was stirred at ambient temperature for 2 hours. The solvents evaporated under reduced pressure to dryness. Yield: 0.8 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06969713B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-c56e4e390156430bbd721ab1d0c53e79 |
| Source note | uspto-grants-2005_11 |