Hydrochloric Acid → 2-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-N-(2-oxo-2,3-dihydro-1H-indol-4-yl)acetamide Hydrochloride Salt

HRID 1064579Notes

Reaction equation

HRID 1064579 reaction equation
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[NH:11][C:12]([CH2:14][N:15]2[CH2:21][CH:20]3[N:22](C(OC(C)(C)C)=O)[CH:17]([CH2:18][CH2:19]3)[CH2:16]2)=[O:13])[NH:3]1.CO.[ClH:32]>O1CCOCC1>[ClH:32].[CH:20]12[NH:22][CH:17]([CH2:18][CH2:19]1)[CH2:16][N:15]([CH2:14][C:12]([NH:11][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]3[C:9]=1[CH2:10][C:2](=[O:1])[NH:3]3)=[O:13])[CH2:21]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 866020003-[(2-Oxo-2,3-dihydro-1H-indol-4ylcarbamoyl)-methyl]-3,8-diazabicyclo[3.2.1]octan-8-carboxylic acid, 1,1-dimethylethyl Ester

Product 1

HCID 697977772-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-N-(2-oxo-2,3-dihydro-1H-indol-4-yl)acetamide Hydrochloride Salt

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

The product of step (ii) (0.8 g) was dissolved in 2M hydrogen chloride in 1,4-dioxane (10 ml), 1,4-dioxane (10 ml), methanol (10 ml) and the reaction mixture was stirred at ambient temperature for 2 hours. The solvents evaporated under reduced pressure to dryness. Yield: 0.8 g

Workup

  1. customThe solvents evaporated under reduced pressure to dryness

Sources & evidence

ORD record
ord-c56e4e390156430bbd721ab1d0c53e79
Source dataset
uspto-grants-2005_11
Patent number
US06969713B2

Reaction notes

Loading…