Hydrazine hydrate (1:1) → HCID 60045700, compound

HRID 1064584Notes

Reaction equation

HRID 1064584 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:31])[CH2:10][N:11]1[CH2:16][C@H:15]([CH3:17])[N:14]([S:18]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([N+:27]([O-])=O)[CH:22]=2)(=[O:20])=[O:19])[C@H:13]([CH3:30])[CH2:12]1.O.NN>C(O)C.[Pd]>[NH2:27][C:23]1[CH:22]=[C:21]([S:18]([N:14]2[C@@H:15]([CH3:17])[CH2:16][N:11]([CH2:10][C:9]([NH:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[CH3:1])=[O:31])[CH2:12][C@H:13]2[CH3:30])(=[O:19])=[O:20])[CH:26]=[CH:25][CH:24]=1

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 60045661HCID 60045661, compound

Product 1

HCID 60045700HCID 60045700, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a stirred solution of the product of Example 56 (3.0 g) in ethanol (1500 ml) was added 5% palladium on charcoal (1.5 g) followed by dropwise addition of hydrazine hydrate (20 ml). The mixture was stirred for 1 hour, filtered through ‘hyflo’ and the filtrate was evaporated to dryness. The solid residue was crystallised from ethanol to give the title compound as a white solid. Yield 1.6 g.

Workup

  1. filtrationfiltered through ‘hyflo’ and the filtrate
  2. customwas evaporated to dryness
  3. customThe solid residue was crystallised from ethanol

Sources & evidence

ORD record
ord-45a14835a0a84d85a1697fb5c6c9d960
Source dataset
uspto-grants-2005_11
Patent number
US06969713B2

Reaction notes

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