3-Cyanobenzene-1-sulfonyl chloride → Cis-2-(4-(3-Cyanobenzenesulphonyl)-3,5-dimethylpiperazin-1-yl)-N-(3-fluoro-2-methylphenyl)acetamide

HRID 1064588Notes

Reaction equation

HRID 1064588 reaction equation
[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:8])[CH2:5][N:4]([CH2:9][C:10]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=2[CH3:20])=[O:11])[CH2:3]1.[C:21]([C:23]1[CH:24]=[C:25]([S:29](Cl)(=[O:31])=[O:30])[CH:26]=[CH:27][CH:28]=1)#[N:22]>>[C:21]([C:23]1[CH:24]=[C:25]([S:29]([N:7]2[C@@H:2]([CH3:1])[CH2:3][N:4]([CH2:9][C:10]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=3[CH3:20])=[O:11])[CH2:5][C@H:6]2[CH3:8])(=[O:31])=[O:30])[CH:26]=[CH:27][CH:28]=1)#[N:22]

Participants

3

Reactant 2

HCID 28013603-Cyanobenzene-1-sulfonyl chlorideHCID 69746587cis-(3,5-Dimethylpiperazin-1-yl)-N-(2-methyl-3-fluorophenyl)acetamide

Product 1

HCID 69745121Cis-2-(4-(3-Cyanobenzenesulphonyl)-3,5-dimethylpiperazin-1-yl)-N-(3-fluoro-2-methylphenyl)acetamide

Procedure

The title compound was prepared from the product of step (i) (0.503 mmol) and 3-cyanobenzenesulphonyl chloride (0.503 mmol) by the method of Example 58 step (ii) as a white solid. Yield: 44 mg

Sources & evidence

ORD record
ord-805793a2c93c4281b13eddb30fa6336f
Source dataset
uspto-grants-2005_11
Patent number
US06969713B2

Reaction notes

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