2-Methanesulfonylbenzene-1-sulfonyl chloride → cis-2-[4-(2-Methanesulphonylbenzenesulphonyl)-3,5-dimethylpiperazin-1-yl]-N-(3 fluoro-2-methylphenyl)acetamide

HRID 1064593Notes

Reaction equation

HRID 1064593 reaction equation
[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:8])[CH2:5][N:4]([CH2:9][C:10]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=2[CH3:20])=[O:11])[CH2:3]1.[CH3:21][S:22]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[S:31](Cl)(=[O:33])=[O:32])(=[O:24])=[O:23]>>[CH3:21][S:22]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[S:31]([N:7]1[C@@H:2]([CH3:1])[CH2:3][N:4]([CH2:9][C:10]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=2[CH3:20])=[O:11])[CH2:5][C@H:6]1[CH3:8])(=[O:33])=[O:32])(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 27351782-Methanesulfonylbenzene-1-sulfonyl chlorideHCID 69746587cis-(3,5-Dimethylpiperazin-1-yl)-N-(2-methyl-3-fluorophenyl)acetamide

Product 1

HCID 60045643cis-2-[4-(2-Methanesulphonylbenzenesulphonyl)-3,5-dimethylpiperazin-1-yl]-N-(3 fluoro-2-methylphenyl)acetamide

Procedure

The title compound was prepared from the product of Example 60 step (i) (0.503 mmol) and 2-methanesulphonylbenzenesulphonyl chloride (0.503 mmol) by the method of Example 58 step (ii) as a white solid. Yield: 17 mg

Sources & evidence

ORD record
ord-4fca2684c77a43a6a2b6a24507b0650a
Source dataset
uspto-grants-2005_11
Patent number
US06969713B2

Reaction notes

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