2-chloro-N-(5-cyano-2-methylphenyl)acetamide → cis-2-[4-(3-Cyanobenzenesulphonyl)-3,5-dimethylpiperazin-1-yl]-n-(5-cyano-2-methylphenyl)acetamide

HRID 1064600Notes

Reaction equation

HRID 1064600 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][C:7]=1[CH3:14])=[O:4].[C:15]([C:17]1[CH:18]=[C:19]([S:23]([N:26]2[C@H:31]([CH3:32])[CH2:30][NH:29][CH2:28][C@@H:27]2[CH3:33])(=[O:25])=[O:24])[CH:20]=[CH:21][CH:22]=1)#[N:16]>>[C:15]([C:17]1[CH:18]=[C:19]([S:23]([N:26]2[C@@H:31]([CH3:32])[CH2:30][N:29]([CH2:2][C:3]([NH:5][C:6]3[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][C:7]=3[CH3:14])=[O:4])[CH2:28][C@H:27]2[CH3:33])(=[O:24])=[O:25])[CH:20]=[CH:21][CH:22]=1)#[N:16]

Participants

3

Reactant 2

HCID 222734112-chloro-N-(5-cyano-2-methylphenyl)acetamideHCID 69744750cis-1-(3-Cyanobenzenesulphonyl)-2,6-dimethylpiperazine

Product 1

HCID 69745774cis-2-[4-(3-Cyanobenzenesulphonyl)-3,5-dimethylpiperazin-1-yl]-n-(5-cyano-2-methylphenyl)acetamide

Procedure

The title compound was prepared from the product of step (i) (0.19 g) and the product from Example 80 step (ii) (0.2 g) by the method of Example 80 step (iii) as a white solid. Yield: 0.25 g

Sources & evidence

ORD record
ord-e70d5c1c298e4bc79df3685c4756b6e0
Source dataset
uspto-grants-2005_11
Patent number
US06969713B2

Reaction notes

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