(2-Fluorophenyl)(4-hydroxy-3-iodophenyl)methanone → (2-fluorophenyl)(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)methanone

HRID 1064721ノート

反応式

HRID 1064721 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[C:12](I)[CH:11]=1)=[O:9].[CH2:18]([N:22]1[CH2:26][CH2:25][CH2:24][C@H:23]1[CH3:27])[CH2:19][C:20]#[CH:21]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([C:10]1[CH:15]=[CH:14][C:13]2[O:16][C:20]([CH2:19][CH2:18][N:22]3[CH2:26][CH2:25][CH2:24][C@H:23]3[CH3:27])=[CH:21][C:12]=2[CH:11]=1)=[O:9]

参加物

3

反応物 2

HCID 11279298(2-Fluorophenyl)(4-hydroxy-3-iodophenyl)methanoneHCID 11367023(R)-1-(But-3-yn-1-yl)-2-methylpyrrolidine

生成物 1

HCID 10154945(2-fluorophenyl)(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)methanone

実験手順

The product from Example 70A and a 0.1M solution of the product from Example 68B were processed as described in Example 68C to provide the title compound. 1HNMR (300 MHz, CD3OD) δ 1.28 (d, 3H, J=6.1 Hz), 1.59 (m, 1H), 1.93 (m, 2H), 2.10-2.78 (m, 2H), 2.93 (m, 2H), 3.18 (m, 2H), 3.45 (m, 2H), 6.76 (s, 1H), 7.21-7.38 (m, 2H), 7-50-7.67 (m, 3H), 7.79 (d, 1H, J=8.9 Hz), 7.99 (s, 1H); MS (ESI) m/z 352.1 (M+H)+.

出典と根拠

ORDレコード
ord-f1c61077bd1c4c96b7eedfac457d8414
出典データセット
uspto-grants-2005_11
特許番号
US06969730B2

反応ノート

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