HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Fluorophenyl)(4-hydroxy-3-iodophenyl)methanone → (2-fluorophenyl)(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Fluorophenyl)(4-hydroxy-3-iodophenyl)methanone | HCID 11279298 | — |
| Reactant | (R)-1-(But-3-yn-1-yl)-2-methylpyrrolidine | HCID 11367023 | — |
| Product | (2-fluorophenyl)(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)methanone | HCID 10154945 | — |
Reaction Steps
The product from Example 70A and a 0.1M solution of the product from Example 68B were processed as described in Example 68C to provide the title compound. 1HNMR (300 MHz, CD3OD) δ 1.28 (d, 3H, J=6.1 Hz), 1.59 (m, 1H), 1.93 (m, 2H), 2.10-2.78 (m, 2H), 2.93 (m, 2H), 3.18 (m, 2H), 3.45 (m, 2H), 6.76 (s, 1H), 7.21-7.38 (m, 2H), 7-50-7.67 (m, 3H), 7.79 (d, 1H, J=8.9 Hz), 7.99 (s, 1H); MS (ESI) m/z 352.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06969730B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-f1c61077bd1c4c96b7eedfac457d8414 |
| Source note | uspto-grants-2005_11 |