(S)-2-methylpyrrolidine hydrobromide → 4-(2-{2-[(2R)-2-methylpyrrolidinyl]ethyl}-2,3-dihydro-1-benzofuran-5-yl)benzonitrile

HRID 1064789Notes

Reaction equation

HRID 1064789 reaction equation
Br.[CH3:2][C@H:3]1[CH2:7][CH2:6][CH2:5][NH:4]1.CS(O[CH2:13][CH2:14][CH:15]1[CH2:19][C:18]2[CH:20]=[C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=3)[CH:22]=[CH:23][C:17]=2[O:16]1)(=O)=O>>[CH3:2][C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:13][CH2:14][CH:15]1[CH2:19][C:18]2[CH:20]=[C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=3)[CH:22]=[CH:23][C:17]=2[O:16]1

Participants

3

Reactant 2

HCID 20779371(S)-2-methylpyrrolidine hydrobromideHCID 222744662-[5-(4-Cyanophenyl)-2,3-dihydro-1-benzofuran-2-yl]ethyl methanesulfonate

Product 1

HCID 429585794-(2-{2-[(2R)-2-methylpyrrolidinyl]ethyl}-2,3-dihydro-1-benzofuran-5-yl)benzonitrile

Procedure

(2S)-2-Methylpyrrolidine hydrobromide and the product from Example 67D are processed as described in Example 1D to provide the titled compound.

Sources & evidence

ORD record
ord-1e27c59d45f34dbc88fb66a4078ab0a8
Source dataset
uspto-grants-2005_11
Patent number
US06969730B2

Reaction notes

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