Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 22272755, compound

HRID 1064800Notes

Reaction equation

HRID 1064800 reaction equation
C(SC1C(NC(=O)CBr)=C(SC(C)C)C=C(C)N=1)(C)C.[O:21]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[N:23]=[C:22]1[S:30][CH2:31][CH2:32][N:33]1[CH2:38][CH2:37][N:36]([CH2:39][C:40]([NH:42][C:43]2[C:44]([S:54][CH:55]([CH3:57])[CH3:56])=[N:45][C:46]([CH3:53])=[CH:47][C:48]=2[S:49][CH:50]([CH3:52])[CH3:51])=[O:41])[CH2:35][CH2:34]1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.[ClH:70].Cl>>[ClH:70].[ClH:70].[O:21]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[N:23]=[C:22]1[S:30][CH2:31][CH2:32][N:33]1[CH2:34][CH2:35][N:36]([CH2:39][C:40]([NH:42][C:43]2[C:44]([S:54][CH:55]([CH3:57])[CH3:56])=[N:45][C:46]([CH3:53])=[CH:47][C:48]=2[S:49][CH:50]([CH3:52])[CH3:51])=[O:41])[CH2:37][CH2:38]1

Participants

4

Reactant 3

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 22247151HCID 22247151, compoundHCID 22272756HCID 22272756, compound

Product 1

HCID 22272755HCID 22272755, compound

Procedure

After that, the same reaction and treatment as in Example 24 were conducted using N-[2,4-bis(isopropylthio)-6-methyl-3-pyridyl]-2-bromoacetamide instead of N-[2,4-bis-(methylthio)-6-methyl-3-pyridyl]-2-bromoacetamide and the resulting 2-[4-[2-(benzoxazol-2-ylthio)-ethyl]piperazin-1-yl]-N-[2,4bis(isopropylthio)-6-methyl-3-pyridyl]acetamide was converted to a dihydrochloride to provide a desired compound as colorless powdery crystals.

Workup

  1. customAfter that, the same reaction and treatment as in Example 24

Sources & evidence

ORD record
ord-150f8dcada4e4c008ea55191127cbba1
Source dataset
uspto-grants-2005_11
Patent number
US06969711B2

Reaction notes

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