Hydrochloric Acid → HCID 22272714, compound

HRID 1064848Notes

Reaction equation

[CH:1]([C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6]([CH:11]([CH3:13])[CH3:12])[C:5]=1[NH:14][C:15](=[O:48])[N:16]([CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])[CH2:17][CH2:18][N:19]1[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][S:27][C:28]2[O:29][C:30]3[C:36]([C:37]([F:40])([F:39])[F:38])=[CH:35][CH:34]=[CH:33][C:31]=3[N:32]=2)[CH2:21][CH2:20]1)([CH3:3])[CH3:2].[ClH:49]>>[ClH:49].[CH:1]([C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6]([CH:11]([CH3:13])[CH3:12])[C:5]=1[NH:14][C:15](=[O:48])[N:16]([CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])[CH2:17][CH2:18][N:19]1[CH2:20][CH2:21][N:22]([CH2:25][CH2:26][S:27][C:28]2[O:29][C:30]3[C:36]([C:37]([F:38])([F:39])[F:40])=[CH:35][CH:34]=[CH:33][C:31]=3[N:32]=2)[CH2:23][CH2:24]1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 22272649HCID 22272649, compound

Product 1

HCID 22272714HCID 22272714, compound

Procedure

This urea compound was then converted into its salt with hydrochloride according to a conventional way and recrystallized from chloroform-hexane to provide the desired compound as colorless needles.

Workup

customrecrystallized from chloroform-hexane

Sources & evidence

ORD record: ord-36adf39ba2b9436e9e6407f799de79d8
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06969711B2

Reaction notes

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