Lithium Hydroxide → (S)-3-{4-[2-(3,5-dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid

HRID 1064895Notes

Reaction equation

HRID 1064895 reaction equation
C[O:2][C:3](=[O:34])[C@@H:4]([O:31][CH2:32][CH3:33])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[N:15]=[C:16]([C:20]3[CH:25]=[C:24]([O:26][CH3:27])[CH:23]=[C:22]([O:28][CH3:29])[CH:21]=3)[O:17][C:18]=2[CH3:19])=[CH:8][C:7]=1[CH3:30].[Li+].[OH-]>>[CH3:29][O:28][C:22]1[CH:21]=[C:20]([C:16]2[O:17][C:18]([CH3:19])=[C:14]([CH2:13][O:12][C:9]3[CH:10]=[CH:11][C:6]([CH2:5][C@H:4]([O:31][CH2:32][CH3:33])[C:3]([OH:34])=[O:2])=[C:7]([CH3:30])[CH:8]=3)[N:15]=2)[CH:25]=[C:24]([O:26][CH3:27])[CH:23]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 69280726(S)-3-{4-[2-(3,5-dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid methyl ester

Product 1

HCID 69283463(S)-3-{4-[2-(3,5-dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid

Procedure

In analogy to the procedure described in example 1 g], (S)-3-{4-[2-(3,5-dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid methyl ester was treated with LiOH to obtain (S)-3-{4-[2-(3,5-dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid as colorless solid.

Sources & evidence

ORD record
ord-50de8f59f65b4282a1c0595ff1069226
Source dataset
uspto-grants-2005_11
Patent number
US06969725B2

Reaction notes

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