Lithium Hydroxide → HCID 69280643, compound

HRID 1064989Notes

Reaction equation

C[O:2][C:3](=[O:33])[C@@H:4]([O:30][CH2:31][CH3:32])[CH2:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[C:23]([CH3:28])[CH:22]=3)[O:18][C:19]=2[CH3:20])=[CH:8][C:7]=1[CH3:29].[Li+].[OH-]>>[CH2:31]([O:30][C@@H:4]([CH2:5][C:6]1[C:7]([CH3:29])=[CH:8][C:9]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[C:23]([CH3:28])[CH:22]=3)[O:18][C:19]=2[CH3:20])=[CH:10][C:11]=1[CH3:12])[C:3]([OH:33])=[O:2])[CH3:32]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69282200HCID 69282200, compound

Product 1

HCID 69280643HCID 69280643, compound

Procedure

In analogy to the procedure described in example 1 g], (S)-2-ethoxy-3-{4-[2-(4-fluoro-3-methyl-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2,6-dimethyl-phenyl}-propionic acid methyl ester was treated with LiOH to obtain (S)-2-ethoxy-3-{4-[2-(4-fluoro-3-methyl-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2,6-dimethyl-phenyl}-propionic acid as colorless solid.

Sources & evidence

ORD record: ord-9114f04eeaa84c4e98942ed97e31701a
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06969725B2

Reaction notes

Loading…