Lithium Hydroxide → HCID 69280735, compound

HRID 1065010Notes

Reaction equation

C[O:2][C:3](=[O:29])[C@@H:4]([O:26][CH2:27][CH3:28])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[N:15]=[C:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[O:17][CH:18]=2)=[CH:8][C:7]=1[CH3:25].[Li+].[OH-]>>[CH2:27]([O:26][C@@H:4]([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[N:15]=[C:16]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[O:17][CH:18]=2)=[CH:8][C:7]=1[CH3:25])[C:3]([OH:29])=[O:2])[CH3:28]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69283472HCID 69283472, compound

Product 1

HCID 69280735HCID 69280735, compound

Procedure

In analogy to the procedure described in example 1 g], (S)-2-ethoxy-3-[2-methyl-4-(2-phenyl-oxazol-4-ylmethoxy)-phenyl]-propionic acid methyl ester was treated with LiOH to obtain (S)-2-ethoxy-3-[2-methyl-4-(2-phenyl-oxazol-4-ylmethoxy)-phenyl]-propionic acid as colorless solid.

Sources & evidence

ORD record: ord-3cb66144001c40eda73e141a09ecd717
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06969725B2

Reaction notes

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