HRID1065059

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID887

Methanol

CH4O

HCID44581473

未命名化合物

PRODUCTS

生成物

结构：CN[C@H]1[C@@H](O[C@@H]2/C3=C/C#C[C@H]4O[C@@]4(C4COC(=O)O4)C#CC3=C[C@H]2OC(=O)c2c(O)ccc3c(C)cc(OC)cc23)O[C@H](C)[C@H](O)[C@@H]1O

HCID13891603

未命名化合物

PROCEDURE

实验过程

Into 1.5 l of a 95% methanol solution was suspended 16 g of neocarzinostatin powder. After adjusting the pH of the suspension with 1 N hydrochloric acid to pH 2.0, the suspension was stirred for 2 hours and then subjected to centrifugal separation. The supernatant was then concentrated and dried to 920 mg of crude powder of the NCS-C substance. The crude powder was subjected to Sephadex LH-20 chromatography in the same manner as in Example 3. The NCS-C substance was obtained in a powder form (yield: 105 mg).

WORKUP

后处理

customsubjected to centrifugal separation
concentrationThe supernatant was then concentrated
dry with materialdried to 920 mg of crude powder of the NCS-C substance

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2a7bca97818c40daacabb3d6fe851fc0
来源数据集: uspto-grants-1982_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04328212
来源说明: uspto-grants-1982_05

反应 SMILES

[CH3:1][C:2]1[C:7]2=[CH:8][CH:9]=[CH:10][C:11]([C:12]([O:14][C@H:15]3[C@H:27]([O:28][C@H:29]4[O:34][C@H:33]([CH3:35])[C@H:32]([OH:36])[C@H:31]([OH:37])[C@H:30]4[NH:38][CH3:39])[C:26]4=[CH:25][C:24]#[C:23][C@H:21]5[O:22][C@@:20]5([C@@H:40]5[O:45][C:43](=[O:44])[O:42][CH2:41]5)[C:19]#[C:18][C:17]4=[CH:16]3)=[O:13])=[C:6]2[CH:5]=[C:4]([O:46][CH3:47])[CH:3]=1.Cl.C[OH:50]>>[CH3:35][C@H:33]1[O:34][C@H:29]([O:28][C@H:27]2[C@H:15]([O:14][C:12]([C:11]3[C:6]4[C:7](=[C:2]([CH3:1])[CH:3]=[C:4]([O:46][CH3:47])[CH:5]=4)[CH:8]=[CH:9][C:10]=3[OH:50])=[O:13])[CH:16]=[C:17]3[C:18]#[C:19][C@:20]4([CH:40]5[O:45][C:43](=[O:44])[O:42][CH2:41]5)[O:22][C@@H:21]4[C:23]#[C:24][CH:25]=[C:26]23)[C@H:30]([NH:38][CH3:39])[C@@H:31]([OH:37])[C@H:32]1[OH:36]