Hydrochloric Acid → HCID 178517108, compound

HRID 1065102Notes

Reaction equation

HRID 1065102 reaction equation
C([O:4][CH2:5][C:6]1[NH:7][N:8]2[C:17]([CH:18]=1)=[C:16]1[C:11]([CH:12]=[CH:13][CH:14]=[CH:15]1)=[N:10][C:9]2=[O:19])(=O)C.[OH-].[Na+].Cl.O>CO>[OH:4][CH2:5][C:6]1[NH:7][N:8]2[C:17]([CH:18]=1)=[C:16]1[C:11]([CH:12]=[CH:13][CH:14]=[CH:15]1)=[N:10][C:9]2=[O:19]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 178475804HCID 178475804, compound

Product 1

HCID 178517108HCID 178517108, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The crude acetate product from Example 5 is slurried in a solution of 0.3 g of sodium hydroxide in 10 ml of aqueous methanol (1:1). After stirring for 5 hours, the reaction mixture is neutralized with concentrated hydrochloric acid followed by the addition of 13 ml of distilled water. After stirring overnight, the product is filtered, washed with cold distilled water and dried under vacuum at 60° C. to 0.62 g (72%) of white product, m.p. 285.0°-288.0° C.

Workup

  1. stirringAfter stirring overnight
  2. filtrationthe product is filtered
  3. washwashed
  4. distillationwith cold distilled water
  5. dry with materialdried under vacuum at 60° C. to 0.62 g (72%) of white product, m.p. 285.0°-288.0° C.

Sources & evidence

ORD record
ord-6bf64dcc631e41daa4c1107f23872244
Source dataset
uspto-grants-1982_05
Patent number
US04328342

Reaction notes

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