反应详情

The crude acetate product from Example 5 is slurried in a solution of 0.3 g of sodium hydroxide in 10 ml of aqueous methanol (1:1). After stirring for 5 hours, the reaction mixture is neutralized with concentrated hydrochloric acid followed by the addition of 13 ml of distilled water. After stirring overnight, the product is filtered, washed with cold distilled water and dried under vacuum at 60° C. to 0.62 g (72%) of white product, m.p. 285.0°-288.0° C.

1. stirringAfter stirring overnight
2. filtrationthe product is filtered
3. washwashed
4. distillationwith cold distilled water
5. dry with materialdried under vacuum at 60° C. to 0.62 g (72%) of white product, m.p. 285.0°-288.0° C.