3,4,5,6-Tetrahydrophthalic anhydride → N-(2-fluoro-4-bromophenyl)-3,4,5,6-tetrahydrophthalamic acid

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Reaction Steps

3,4,5,6-tetrahydrophthalic anhydride (16.0 g) and 2-fluoro-4-bromoaniline (20.0 g) were added to acetone (100 ml) and, after stirring at 40°-45° C. for 2 hours, the mixture was concentrated to dryness under reduced pressure. The resultant crystals were washed with n-hexane. Yield 30.3 g.; m.p. 98°-99° C.

Provenance & Evidence