Acetone → HCID 12906590, compound

HRID 1065188Notes

Reaction equation

HRID 1065188 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:14](=[O:15])[CH:13]2[CH2:16][CH2:17][CH2:18][C:11](=[CH:12]2)C1=O.[CH:20]([NH2:23])([CH3:22])[CH3:21].C[C:25](C)=[O:26]>>[CH:20]([NH:23][C:25](=[O:26])[C:16]1[CH2:17][CH2:18][CH2:11][CH2:12][C:13]=1[C:14]([NH:9][C:3]1[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=1[F:1])=[O:15])([CH3:22])[CH3:21]

Participants

4

Reactant 3

HCID 180AcetoneHCID 6363IsopropylamineHCID 20541559HCID 20541559, compound

Product 1

HCID 12906590HCID 12906590, compound

Procedure

In acetone (40 ml) was dissolved N-(2-fluoro-4-chlorophenyl)-3,4,5,6-tetrahydroisophthalimide (2.8 g) and while stirring at room temperature, isopropylamine (0.6 g) was added. The mixture was allowed to stand for 10 hours, after which time the precipitate was recovered by filtration and washed with acetone. Yield 3.0 g.; m.p. 188°-189° C.

Workup

  1. filtrationafter which time the precipitate was recovered by filtration
  2. washwashed with acetone

Sources & evidence

ORD record
ord-973737407e93412f8535932eb45883a4
Source dataset
uspto-grants-1982_05
Patent number
US04328367

Reaction notes

Loading…