Formic Acid → HCID 20539872, compound

HRID 1065206Notes

Reaction equation

HRID 1065206 reaction equation
[NH:1]([CH:3]([C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)[C:4]([OH:6])=[O:5])[NH2:2].C[C:13](C(OC(C(C)=O)=O)=O)=[O:14].[CH:23](O)=[O:24]>>[CH:13]([N:1]([CH:3]([C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)[C:4]([OH:6])=[O:5])[NH:2][CH:23]=[O:24])=[O:14]

Participants

4

Reactant 3

HCID 284Formic AcidHCID 12282364HCID 12282364, compoundHCID 52937935HCID 52937935, compound

Product 1

HCID 20539872HCID 20539872, compound

Procedure

A solution of 1 g (RS) α-hydrazino-2-thienylacetic acid in 3 ml formic acid is stirred at 4° C. and treated dropwise with a solution of 3 ml acetoformic anhydride. Stirring is continued for 20 minutes at the same temperature and for a further 30 minutes at ambient temperature, then the product is evaporated to dryness, taken up with diethyl ether and the so obtained solid is triturated with ethyl ether collected under vacuum, to give 1.26 g (RS) α-(1.2-diformylhydrazino)-2-thienylacetic acid melting at 168°-170° C. (with decomposition).

Workup

  1. customthe product is evaporated to dryness
  2. customthe so obtained solid is triturated with ethyl ether
  3. customcollected under vacuum

Sources & evidence

ORD record
ord-6e4ce29894b649bd88c18b2056ccd1be
Source dataset
uspto-grants-1982_05
Patent number
US04329285

Reaction notes

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