Formic Acid → HCID 20539872, compound

Participants

Reaction Steps

A solution of 1 g (RS) α-hydrazino-2-thienylacetic acid in 3 ml formic acid is stirred at 4° C. and treated dropwise with a solution of 3 ml acetoformic anhydride. Stirring is continued for 20 minutes at the same temperature and for a further 30 minutes at ambient temperature, then the product is evaporated to dryness, taken up with diethyl ether and the so obtained solid is triturated with ethyl ether collected under vacuum, to give 1.26 g (RS) α-(1.2-diformylhydrazino)-2-thienylacetic acid melting at 168°-170° C. (with decomposition).

Provenance & Evidence