Sodium Carbonate → HCID 12850587, compound

HRID 1065238Notes

Reaction equation

HRID 1065238 reaction equation
S(O[CH2:12][CH2:13][CH:14]1[O:19][C:18]2[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=2[O:16][CH2:15]1)(C1C=CC(C)=CC=1)(=O)=O.[NH:24]1[CH2:29][CH2:28][CH:27]([N:30]2[CH2:34][CH2:33][NH:32][C:31]2=[O:35])[CH2:26][CH2:25]1.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)CC(=O)C>[O:19]1[C:18]2[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=2[O:16][CH2:15][CH:14]1[CH2:13][CH2:12][N:24]1[CH2:25][CH2:26][CH:27]([N:30]2[CH2:34][CH2:33][NH:32][C:31]2=[O:35])[CH2:28][CH2:29]1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 128505822-(2-Tosyloxyethyl)-1,4-benzodioxanHCID 130317571-(Piperidin-4-yl)imidazolidin-2-one

Product 1

HCID 12850587HCID 12850587, compound

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

The mixture of 4.9 g of 2-(2-tosyloxyethyl)-1,4-benzodioxan, 2.54 g of 1-(4-piperidyl)-2-imidazolidinone, 5 g of anhydrous sodium carbonate and 100 ml of 4-methyl-2-pentanone is stirred and refluxed for 3 days. It is filtered, evaporated and the residue recrystallized from isopropanol, to yield the 1-[1-[2-(1,4-benzodioxan-2-yl)-ethyl]-4-piperidyl]-2-imidazolidinone of the formula ##STR9## melting at 125°.

Workup

  1. temperaturerefluxed for 3 days
  2. filtrationIt is filtered
  3. customevaporated
  4. customthe residue recrystallized from isopropanol

Sources & evidence

ORD record
ord-9d7c9c7972d349fbaefdb7ce77710c72
Source dataset
uspto-grants-1982_05
Patent number
US04329348

Reaction notes

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