Hydrochloric Acid → HCID 20540158, compound

HRID 1065241Notes

Reaction equation

HRID 1065241 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH:16]([NH:19][CH2:20][CH2:21][NH2:22])[CH2:15][CH2:14]1.[ClH:23].[C:24](=S)=[S:25]>C(O)C>[ClH:23].[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH:16]([N:19]2[CH2:20][CH2:21][NH:22][C:24]2=[S:25])[CH2:15][CH2:14]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6348Carbon DisulfideHCID 20540171HCID 20540171, compound

Product 1

HCID 20540158HCID 20540158, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To the stirred solution of 6 g of 1-[2-(1,4-benzodioxan-2-yl)-ethyl]-4-(2-aminoethylamino)-piperidine in 10 ml of 50% aqueous ethanol, 1.4 ml of carbon disulfide are added dropwise at 25°. The mixture is refluxed for one hour, a drop of concentrated hydrochloric acid is added and refluxing is continued for 5 hours. After cooling overnight the mixture is filtered and the residue washed with ethanol, to yield the 1-[1-[2-(1,4-benzodioxan-2-yl)-ethyl]-4-piperidyl]-2-imidazolidinthione hydrochloride melting at 292°.

Workup

  1. temperatureThe mixture is refluxed for one hour
  2. temperaturerefluxing
  3. temperatureAfter cooling overnight the mixture
  4. filtrationis filtered
  5. washthe residue washed with ethanol

Sources & evidence

ORD record
ord-91932252e40049f8b19da66da66abb1b
Source dataset
uspto-grants-1982_05
Patent number
US04329348

Reaction notes

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