反应详情

A mixture of 40 parts of 8-(4-fluorophenyl)-1,4-dioxaspiro[4,5]decane-8-carboxylic acid, 100 parts of a hydrochloric acid solution 6 N and 100 parts of acetic acid is started and refluxed overnight. The reaction mixture is cooled and the product is extracted with trichloromethane. The extract is washed three times with water, dried, filtered and evaporated, yielding 17 parts (50%) of 1-(4-fluorophenyl)-4-oxocyclohexanecarboxylic acid as a residue.

1. temperaturerefluxed overnight
2. temperatureThe reaction mixture is cooled
3. extractionthe product is extracted with trichloromethane
4. washThe extract is washed three times with water
5. customdried
6. filtrationfiltered
7. customevaporated